The Arctic Liquid Freezer III 280 is the objective winner of this comparison, securing more individual specification victories than its competitor. Its most significant advantage is its MSRP, which is 52% better than that of the DeepCool Mystique 360. While the latter holds a lead in radiator size, the Arctic Liquid Freezer III 280 provides a more favorable value proposition based on the provided specifications, making it the superior choice for those prioritizing cost-efficiency in their cooling solution.

Users should select the Arctic Liquid Freezer III 280 if they are looking to maximize their budget, as its primary strength lies in its superior MSRP. Conversely, the DeepCool Mystique 360 is the better option for builders who prioritize radiator size, as it offers a 29% advantage in that specific category. Choosing between these two coolers depends entirely on whether the user values the significant cost savings of the Arctic model or the larger radiator dimensions of the DeepCool unit.