The Framework Laptop 16 is the objective winner of this comparison, securing a higher number of superior specifications across the evaluated fields. Its most significant advantage lies in its USB-C connectivity, which offers a 200% increase in port availability compared to the alternative. This hardware configuration provides a clear lead in overall versatility and interface options, establishing the Framework Laptop 16 as the more robust choice for users prioritizing expanded peripheral support and modular connectivity.

Users who require maximum USB-C integration should select the Framework Laptop 16 for its superior port density. Conversely, those who prioritize high-speed data transfer and specialized peripheral compatibility should choose the Lenovo ThinkPad P16s Gen 3, which holds a 100% advantage in Thunderbolt port capacity. Selecting between these two devices depends entirely on whether your workflow demands the broader USB-C connectivity provided by the Framework or the specific Thunderbolt interface benefits offered by the Lenovo.