The Samsung 9100 Pro 4TB is the objective winner of this comparison, securing more individual specification victories than its competitor. Its most significant advantage is a sequential read speed that is 103% better than the alternative. While both drives share identical performance in three measured categories, the Samsung 9100 Pro 4TB clearly outperforms the Western Digital WD Black SN850X 4TB in raw data retrieval capabilities, establishing it as the superior option for users prioritizing high-speed throughput.

Users who require maximum sequential read performance should choose the Samsung 9100 Pro 4TB to leverage its substantial speed advantage. Conversely, the Western Digital WD Black SN850X 4TB is the better choice for budget-conscious buyers, as it offers a 21% better MSRP. Because both drives are tied in three key specifications, the final decision rests on whether the user values the significant read speed lead of the Samsung drive or the cost efficiency of the Western Digital model.